Outputs

Conventional publications

Publications are listed here. We are fervent advocates of open science and open data, with some manuscripts hosted in bioRxiv, and all R codes and scripts on our mixOmics page.

Fun publications

(refereed by editorial board)

Huang BE, Clifford D and Lê Cao K-A (2014). The surprising benefit of passive-aggressive behaviour at Christmas parties: being crowned king of the crackers. Medical Journal of Australia 201(11):694-6 (Christmas issue, awarded first prize, radio interview from ABC Darwin, mentioned in the podcast from Two Shrink Pod (episode 21, Dec 2017).

Clifford D, Lê Cao K-A and Huang BE (2014). The statistician’s guide to a cracking good Christmas party. Significance 11(5):44-7 (Christmas issue, doi: 10.1111/j.1740- 9713.2014.00784.x).

Awards and fellowships

2019 – 2022 Career Development Fellowship (CDF2) from the National Health and Medical Council Research (NHMRC)Microbiome biomarkers of human disease: novel computational methods to facilitate therapeutic developments’, $483K.

2015 – 2019 Career Development Fellowship (CDF1) from the National Health and Medical Council Research (NHMRC) ‘Development of statistical methodologies and application to clinical cancer studies’, $419K.

2009             Laurent-Duhamel triennial prize from the French Statistical Society for PhD thesis in Applied Statistics, Bordeaux, France.

Current funding (UoM)

2018 – 2019  Silicon Valley Community Foundation, HCA2-A-1708-02277, Multivariate computational methods for data integration of single cell assays. Role: CIA. $132K

2018             UoM Computational Biology Research Initiative seed funding. Towards the understanding of gut-brain crosstalk in Huntington’s disease. Role: CIA. $20K.

2018 – 2021 NHMRC Project Grant, GNT1142456. Enhancing host defence mechanisms in severe bacterial infections. Dr A Blumenthal, Prof B Venkatesh, Prof D Evans, Dr K-A Lê Cao,  Prof G Ulett, A/Prof J Cohen. Role: CID. $837K

2018 – 2021 NHMRC Project Grant. GNT1144941. Understanding how azithromycin prevents exacerbations in severe asthma. Prof J Upham, Prof J Simpson, Dr K Baines, Dr K- A Lê Cao. Role: CID. $698K

2018 – 2019 ARC Special Research Initiative in Stem cells Centre of Excellence, Stem Cells Australia led by Prof M Little (UoM). Role: co-CI. $3M, 1 research fellow in Lê Cao group.

Patents

The application of our methods and software has directly resulted in four biomedical patents.

  1. Gandhi M, Keane C, Lê Cao K-A, Vari F (2015). A method of assessing prognosis of lymphoma. WO/2016/134416. Priority 23/02/2016
  2. Thomas R, Mehdi A, Lê Cao K-A (2014). Kits and methods for the diagnosis, treatment, prevention and monitoring of diabetes. PCT/AU2014/050415. Priority 18/06/2015
  3. Hill M, Shah A, Lê Cao K-A (2014). Blood Test for Throat Cancer. WO/2016/077881. Priority 17/11/2015
  4. Musso O, Desert R, Rohart F, Lê Cao K-A. Method for predicting the survival time of a patient suffering from hepatocellular Carcinoma. EP17305436.2. Priority 12/04/2017

Past funding (University of Queensland)

2016             Translational Research Institute SPORE grant, Obesity-induced Barrett’s oesophagus and associated cancer: mechanisms and diagnostic tools. A/Prof M. Hill, Dr A. Barbour, Dr K-A. Lê Cao (CIC). $100K

2016             Translational Research Institute SPORE grant, Towards biomarkers for patient stratification in sepsis, Dr A. Blumenthal, Prof B. Venkatesh, A/Prof J Cohen, Dr K-A. Lê Cao, Dr D. Vagenas, Prof I. Frazer (CID). $80K

2014 – 2015  The Juvenile Diabetes Research Foundation (JDRF), 2-SRA-2015-306-Q-R, A genetic link between gut microbial flora and T1D susceptibility. Dr D. Zipris (University of Colorado) and co-CI from UQDI: Dr E. Hamilton-Williams, Dr J. Mullaney, A/Prof M. Hill, Dr K-A. Lê Cao (PI). $500K

2014             The Juvenile Diabetes Research Foundation (JDRF), 1-PNF-2014-153-A-V, Risk of diabetes progression in at-risk subjects with metabolic and inflammatory signatures. Prof R. Thomas (UQDI), K-A. Lê Cao et al. (PI). $110K

2014             UQ Major Equipment and Infrastructure, 2014000102, High throughput gene expression of patient samples via the Nanostring nCounter system. 
Prof M. Gandhi and 9 co-CI from UQDI, K-A. Lê Cao (CIJ). $169K

2014 – 2016  NHMRC Project Grants Funding, APP1058993, Blood biomarkers in Hodgkin Lymphoma. Prof M. Gandhi, Prof M. Fulham, A/Prof J. Trotman, Dr K-A. Lê Cao, Dr L. Berkahn. (CID)$513K

2013 – 2015  ARC Discovery Project, DP130100777. The Stemformatics gene expression compendium: development of multivariate statistical approaches for cross platform analyses. A/Prof C. Wells, Dr K-A. Lê Cao (CIB). $269K, shared postdoctoral fellow.